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Paul Matthews

OBE, MA, DPhil, MD (Stanford), FRCPC, FRCP, FMedSci
Neurology/Clinical Medicine/Imaging (PET, MRI)/Neuroinflammation/Multiple Sclerosis/Dementia


Professor Matthews’ research interests address the neuropathology and treatment of multiple sclerosis, the role of neuroinflammatory mechanisms in neurodegeneration and in the application of “Big Data” approaches for personalized medicine. His work employs a wide range of ‘omics, epidemiological and imaging methods to address particularly the functional anatomical evolution of innate immune changes in the aging brain in neurodegenerative diseases.  Recent studies have focused on ways that these approaches could be used to better inform individualized estimates of disease risk and personalized medicine for multiple sclerosis and the dementias.

Representative Publications

Poldrack RA, Baker CI, Durnez J, Gorgolewski KJ, Matthews PM, Munafò MR, Nichols TE, Poline JB, Vul E, Yarkoni T. Scanning the horizon: towards transparent and reproducible neuroimaging research. Nat Rev Neurosci. 2017

Feb; 18(2):115-126.

Miller KL, Alfaro-Almagro F, Bangerter NK, Thomas DL, Yacoub E, Xu J, Bartsch AJ, Jbabdi S, Sotiropoulos SN, Andersson JL, Griffanti L, Douaud G, Okell TW, Weale P, Dragonu I, Garratt S, Hudson S, Collins R, Jenkinson M, Matthews PM, Smith SM. 2016. Multimodal population brain imaging in the UK Biobank prospective epidemiological study. Nat Neurosci 19(11): 1523-1536.

Matthews PM, Hampshire A. Clinical Concepts Emerging from fMRI Functional Connectomics. Neuron. 2016 Aug 3;91(3):511-28.

Colasanti A, Guo Q, Giannetti P, Wall MB, Newbould RD, Bishop C, Onega M, Nicholas R, Ciccarelli O, Muraro PA, Malik O, Owen DR, Young AH, Gunn RN, Piccini P, Matthews PM, Rabiner EA. Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis. Biol Psychiatry. 2016 Jul 1;80(1):62-72

Gafson A, Craner MJ, Matthews PM. 2016. Personalised medicine for multiple sclerosis care. Mult Scler. 26 Sept. Epub ahead of print.

Jacobs HI, Wiese S, van de Ven V, Gronenschild EH, Verhey FR, Matthews PM. 2015. Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia. Neurobiol aging. 36(2):618-26

Colasanti A, Guo Q, Muhlert N, Giannetti P, Onega M, Newbould RD, Ciccarelli O, Rison S, Thomas C, Nicholas R, Muraro PA, Malik O, Owen DR, Piccini P, Gunn RN, Rabiner EA, Matthews PM. 2014. In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with 18F-PBR111 PET. J Nucl Med. 55(7):1112-1118